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<p><span style="font-size:16px">The other method is that visualizing the localization of mRNA by hybridization method. <em>In situ </em>hybridization is the one of the best method to visualize the expression of mRNA in cell. When we tagged fluorescence probe with RNA oligomer which has complement sequence for target mRNA, then it will be fluorescence <em>in situ </em>hybridization(FISH) method.&nbsp;FISH <span style="background-color:rgb(255,255,255); color:rgb(37,37,37)">&nbsp;is a&nbsp;</span>cytogenetic<span style="background-color:rgb(255,255,255); color:rgb(37,37,37)">&nbsp;technique that uses&nbsp;</span>fluorescent probes<span style="background-color:rgb(255,255,255); color:rgb(37,37,37)">&nbsp;that bind to only those parts of the chromosome with a high degree of sequence&nbsp;</span>complementarity<span style="background-color:rgb(255,255,255); color:rgb(37,37,37)">.</span></span></p> <p><span style="font-size:16px"><span style="background-color:rgb(255,255,255); color:rgb(37,37,37)"><img alt="" src="/ckfinder/userfiles/images/stellaris-method(1).png" /></span></span></p>

<p><span style="font-size:16px">&nbsp;After transcription of mRNA, then they will be translated by ribosome and tRNA and become newly synthesized polypeptides. Those polypeptides will be modified by other molecules or enzyme to become functional protein. In this stage we can apply the&nbsp;proteomics&nbsp;which is the study of&nbsp;the whole set of proteins. Newly synthesized protein was come from the mRNA, so&nbsp;transcriptome and proteome&nbsp;have&nbsp;very intimate relationship. </span></p>

<p><span style="font-size:16px">UTR is untranslated region in mRNA. mRNA has the structure </span></p>