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From Biolecture.org
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<li>History and the future of genomics? Genomics largely depends on sequencing technology. Early sequencing takes advantages of electrophoresis with chain-termination method invented by Frederick Sanger. Nowadays, it is supplemented by "NGS" - next generation sequencing which is automated, and high-throughput method. There is a very descriptive movie about NGS sequencing[8]. In the future, genomics might provide better sequencing method in terms of processivity, cost, and fidelity. </li>
<li>What is the relationship with other omics? other than genomics, there are lot of -omics such as transcriptomics, proteomics, and so on. Genome is set of instructions of organisms containing all essential genetic information to live on. Therefore, genomics is starting point of -omics study. Genomics explains well difference between distinct organisms such as pine tree and pine beetle becuase they have completely diffenent sturcture of their own genome - but still there's lot of common information they have. However, for example, genomics is poor at demonstrating of difference in organs multicellular organims as they have same genomes - which is called "genetic equivalent". Transcriptomics and proteomics are better than genomics in this case. They can figure out what makes difference in terms of RNA and protein. Although those two -omics are based on genomics, it can focus on the smaller differences what genomics can't. Therefore, Genomics gives basis to other omics, and they provides delicate but significant clues about function of genomes.</li>
<li>How can we engineer genomics?Due to the fact that genomes are set of instruction of living things, one can intuitively manipulate organism in genome level. Therefore, by inserting, deleting, altering genetic information, one can change phenotype of organisms - from ill to health, and activating or knock out, for example. Surprisingly, there are some mechanisms discovered as defensive system for microorganism - restriction enzymes. Having specificity and accuracy, restriction enzymes provides the fidelity in the engineering process. Other than that, Some DNA binding proteins are used for specific binding to target sequence - CRISPR/Cas 9 is well known example.</li>
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