Changes
From Biolecture.org
no edit summary
<li>relationship between trasncriptome & proteome. to cell function, a set of proteins are needed. Due to the fact that mRNA translates proteins it is easy to consider that linear correlation bewteen transcriptome and proteome, low correlation sometimes come up with the post translational modification[3]. but still transcriptomic is the middle step of understanding bewteen genetic code and the functioning molecule.</li>
<li>what is UTR[4]? UTR is abbreviation for untranslated region. it is the portion of mRNA which is not translated. there are two UTR - one is on the 5' end(5'-UTR), another on the 3' end(3'-UTR). those UTRs are related to modification and lifespan of mRNA. for example, polyadenylation is an addition of 200 ~ 300 adenine to 3' end of mRNA making poly A tail. this process depends on AATAAA sequence on the 3'-UTR.</li>
<li>what is ncRNA?ncRNA is abbreviation for non-coding RNA, which means RNA does not encode protein. rather than encoding RNA, such RNAs included regulatory pathway in gene expression. For example, miRNA is transcribed from nucleus and forms complex with proteins. the complex is called RISC(RNA-induced silencing complex), widely regulating eukaryotic gene expression</li>
<li>what is poly A[4]? poly A is the long A sequence on the 3' end of mRNA. it is important for mRNA to fully function as genetic code for protein synthesis. there are 3 roles of poly A tail. 1) providing stability to mRNA, 2)recognizing mRNA for exporting from the nucleus or ribosome binding. 3)involving posttranscriptional modification by interacting with PABP(poly A binding protein), maskin, RISC, and so on.</li>
</ol>
<p>[3] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637682/</p>
<p>[4] Gilbert, Scott F. <i>Developmental Biology</i>. Sunderland, MA: Sinauer Associates, 2010. Print.</p>
<p>[5] </p>
