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<p><span lang="EN-US">3-2 Origin, history and future of Genomics.</span><span lang="EN-US"><br />
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<p><span lang="EN-US">In 1975 Plus and Minus technique was developed. The refinement of the Plus and Minus method resulted in the chain-termination, or Sanger method which formed the basis of the techniques of DNA sequencing, genome mapping, data storage, and bioinformatic analysis most widely used in the following quarter-century of research. In the same year, the Maxam-Gilbert method was developed which is method of DNA sequencing. In the future, there will be more effective method to sequence DNA.<o:p></o:p></span><span lang="EN-US"><br />
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