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<p><Students 1) Define Genomics your own way after doing research on what genomes are asked to do>and how we study.</p>
<p>1) Define Genomics your own way after doing research on what genomes are and how we study. </p>
<pul> <li>It is about sequencing of DNA Genomes - total / mRNA / proteome and analyzing the function and structure of genes genome (especially whole genome in a cell or speciesorganism)</li> <li>difference from genetics : genetic study the detail of function or composition of a single gene whereas genomics cover all genes and their relationship.</pli></ul>
<p> Genomics - The study of sturcures or function of genomes</p> <p> </p>
<p>2) What is the origin of genomics?</p>
<pul>genome <li>genomics = gene + omics(</li> <li> <ul> <li>gene = locus of DNA containing genetic information which is mostly related to phenotype</li> <li>omics =a field of study in biology)class >> proteomics ,metabolomics ,lipidomics , transcriptomics...</li> </ul> </li></pul>
<p>3) History of genomics?</p>
<pul>https <li>1952 ://en.wikipedia.org/wiki/Genomics helical structure of DNA (referenceRosaline Franklin)</pli> <pli>From the Greek ΓΕΝ<em>gen</em>, "gene" 1953 : structure of DNA (gammaJames D, epsilonWatson , nu, epsilonFrancis Crick ) meaning "become, create, creation, birth", and subsequent variants: genealogy, genesis, genetics, genic, genomere, genotype, genus etc. While the word <em/li>genome </emli> 1955 : Amino acid sequence of insulin (from the Fred Sanger)<a href="https://en.wikipedia.org/wiki/German_language" title="German language"li>German </ali>1964 : first nucleic acid sequence  gt;<em>Genom</em>, attributed to gt;<a href="https://enribonucleotide sequence of alanine tRNA (Robert W.wikipedia.org/wiki/Hans_Winkler" title="Hans Winkler">Hans Winkler</a>Holley) was in use in <a href="https://en.wikipedia.org/wiki/English_language" title="English language">English</ali> as early as 1926, the term <emli>genomics</em> was coined by Tom Roderick, a <a href="https1972 ://en.wikipedia.org/wiki/Geneticist" title="Geneticist">geneticist</a>gene sequence for Bacteriophage MS2 ( Walter Fiers) at the <a href="https://en.wikipedia.org/wiki/Jackson_Laboratory" title="Jackson Laboratory">Jackson Laboratory</ali> , over beer at a meeting held in <a href="https://en.wikipedia.org/wiki/Maryland" title="Maryland">Maryland</a> on the mapping of the human genome in 1986.</pul>
<p>4) The future of genomics?</p>
<pul>The answer is shown in youtube video. <li>Personal genomics</pli> <li> <pul>This will <li>definition : sequencing individual genomes</li> <li>why needed? every personal genome sequencing are different, so there may be more used in future some side effect from public drug or chemicals If certain person has specific gene sensitive to the drugs. personal genomics is able to carry genome sequencing from each person and by comparing genomes between organismsdoing this, we can reach ideal drugs optimum to each person.</pli> <li>application (effect) : physiology / drugs / personal information of genetic disease / genetic variants</li> </ul> </li></ul>
<p>5) What is the relationship with other omics?</p>
<pul>Omics means <li>functional genomics looks for the field of study in biology protein function and interaction, so genomics, metabolomics and preteomics are all related.they sometimes use transcriptomics or proteomics to know what kinds of function certain protein or transcriptome have </li></pul>
<p>6) How can we engineer genomes?</p>
<pul> <strongli>Genome engineeringmodify genomic sequence --> repair mutated genes.</strongli> refers to the strategies and techniques developed in recent years for the targeted, specific modification of the genetic information or genome of living organisms. </pul>
<p>Early approaches to genome engineering involved modifying genetic sequences using only homologous recombination. Using a homologous sequence located on another strand as a model can lead this natural DNA maintenance mechanism to repair a DNA strand. It is possible to induce homologous recombinations between a cellular DNA strand and an exogenous DNA strand inserted in the cell by researchers, using a vector such as the modified genome of a retrovirus. The recombination phenomenon is flexible enough for a certain level of change (addition, suppression or modification of a DNA portion) to be introduced to the targeted homologous area.</p>
<phr /><strongp>homologous recombination, Insertion ,Inactivation, or “knock-out” and Correction aims to remove and replace a defective gene sequence with a functional sequence. </strong></p>
<p><strong><Video sources></strong>Types of genomics</p>
<pul>https <li>Cognitive genomics :changes in cognitive processes</li> <li>Comparative genomics : study the relationship between structure and function</wwwli> <li>Functional genomics : study of function and interaction of certain genomes</li> <li>Metagenomics : environmental genomics, study of genetic material recovered directly from environmental samples.youtube.com</li> <li>Personal genomics : personalized genomics targeted for individual genome sequencing</li> <li>Epigenomics : set of epigenetic modification</watch?t=20&v=J7AWWpG52zgli></pul>
<p>After viewing : </p>
<p>The title is the new age of genomics.effect</p>
<pul>Human genomes is now we <li>gene-based understanding of complex biomolecules'nbsp;re sort </li> <li>study of looking on a global scale how life using the bio code software creates what we see around us.intragenomic phenomena or their mutation</li></pul>
<p> </p>
<p><strong><Reference></strong></p> <p>http://www.theverge.com/2015/1/6/7501075/bowheadDNA-whale-genome-longevity-first-time-large-whale</p> <p>The title is Bowhead whale genome may unlock its longevity secrets.</p> <p>Scientists have finally sequenced the genome of a large whale and analyzed by comparing genomes resulting in helping humans live longer.sequencing</p>
<pul>Genomics is perhaps the first such an automated way of pinpointing exact aging associated mutations in such <li><a short timehref="http://www.mun.ca/biology/scarr/4241_StepstowardsDNASequencing.html"><em>Plus and minus technique</em></a></li> <li><a href="https://www.youtube.com/watch?v=iTBTHmhNNbE">Sanger method</a></li> <li><a href="https://www.youtube.com/watch?v=tiG-rxkhlqg">Maxam-Gilbert method</a></li></pul>
