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From Biolecture.org
Created page with "<p>My question is - is it effective/ inspiring/efficient/rational/relevant to study nervous system and problems associated with it by using genomics techniques () </p> <p>&..."
<p>My question is - is it effective/ inspiring/efficient/rational/relevant to study nervous system and problems associated with it by using genomics techniques () </p>
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<p>I will argue here that</p>
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<p>I believe that </p>
<p> </p>
<p> </p>
<p>I will ... </p>
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<p>"An additional, sometimes unspoken, impediment to the more widespread adoption of ‘- omics’ fields (‘omics’) in neuroscience research is an underlying tension between the hypothesis-testing approach applied in the typical neurobiology laboratory</p>
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<p>and the discovery-based disciplines of genetics, genomics, and proteomics (Box 1)."</p>
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<p>The omics view is that an understanding of the organization and structure of the genome and the high-throughput measurements of the relationships of its elements, or gene products, provides a systematic basis on which to</p>
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<p> </p>
<p>understand biological processes.Furthermore, significant value is placed on resource building and data sharing.</p>
<p> </p>
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<p> </p>
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<p>These approaches, which provide a new framework for the rapidly growing fields of neurogenetics, neurogenomics and systems biology, and the challenges that accompany them, are the subject of this Review.</p>
<p> </p>
<p> </p>
<p>We discuss the value of data sharing and provide some key examples of neuroinformatics-based or omics-based resources, highlighting areas in which genetic and functional genomic approaches have brought new biological insight to different areas of neuroscience.</p>
<p> </p>
<p> </p>
<p>We conclude with a discussion of the new frontiers in biological networks and systems biology.</p>
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<p>1. Structure: <strong>essays should make an argument: </strong>your essay should have a point and reach a conclusion, even if tentative, and you should try to convince the reader that your point is correct.</p>
<p> </p>
<p> </p>
<p>This is the most important single point in writing a good essay. It will help you make it well organized, and well-written. Clarity of thought and argument provide the necessary basis for a clear writing style. </p>
<p> </p>
<p> </p>
<p>2. It is key to back up each crucial point that you make with data. Don't just cite the study, but briefly, describe its key result(s) in a sentence or two, and explain, explicitly, why this supports your point.</p>
<p> </p>
<p> </p>
<p>Any statements of nonobvious fact (e.g. "monkeys can follow gaze", or "dopamine is necessary for motor function") should be followed by a reference (even if only to a textbook).</p>
<p> </p>
<p> </p>
<p>3. Proof: Note that the logic of scientific discovery is that of generating a list of possibilities (postulating hypotheses) and then doing experiments to test them. We proceed by rejecting false hypotheses, rather than proving true ones.</p>
<p> </p>
<p> </p>
<p> </p>
<p> </p>
<p> </p>
<p><strong>(What counts as a good argument, or a solid conclusion? There is room for considerable creativity here, depending on the topic. It is easier to say what does not count as a good conclusion.</strong></p>
<p> </p>
<p> </p>
<p><strong>For example, you should never just review a study or studies, and conclude that "more work is necessary".</strong></p>
<p> </p>
<p> </p>
<p><strong>More work is always necessary, and YOUR work in this essay is to reach a more substantive conclusion than that.</strong></p>
<p> </p>
<p> </p>
<p><strong>A recapitulation of some experiments with no substantive conclusions does not constitute a good essay, however accurate.)</strong></p>
<p> </p>
<p> </p>
<p> </p>
<p> </p>
<p>I will argue here that</p>
<p> </p>
<p> </p>
<p>I believe that </p>
<p> </p>
<p> </p>
<p>I will ... </p>
<p> </p>
<p> </p>
<p>"An additional, sometimes unspoken, impediment to the more widespread adoption of ‘- omics’ fields (‘omics’) in neuroscience research is an underlying tension between the hypothesis-testing approach applied in the typical neurobiology laboratory</p>
<p> </p>
<p> </p>
<p>and the discovery-based disciplines of genetics, genomics, and proteomics (Box 1)."</p>
<p> </p>
<p> </p>
<p>The omics view is that an understanding of the organization and structure of the genome and the high-throughput measurements of the relationships of its elements, or gene products, provides a systematic basis on which to</p>
<p> </p>
<p> </p>
<p>understand biological processes.Furthermore, significant value is placed on resource building and data sharing.</p>
<p> </p>
<p> </p>
<p> </p>
<p> </p>
<p> </p>
<p>These approaches, which provide a new framework for the rapidly growing fields of neurogenetics, neurogenomics and systems biology, and the challenges that accompany them, are the subject of this Review.</p>
<p> </p>
<p> </p>
<p>We discuss the value of data sharing and provide some key examples of neuroinformatics-based or omics-based resources, highlighting areas in which genetic and functional genomic approaches have brought new biological insight to different areas of neuroscience.</p>
<p> </p>
<p> </p>
<p>We conclude with a discussion of the new frontiers in biological networks and systems biology.</p>
<p> </p>
<p> </p>
<p> </p>
<p> </p>
<p> </p>
<p>1. Structure: <strong>essays should make an argument: </strong>your essay should have a point and reach a conclusion, even if tentative, and you should try to convince the reader that your point is correct.</p>
<p> </p>
<p> </p>
<p>This is the most important single point in writing a good essay. It will help you make it well organized, and well-written. Clarity of thought and argument provide the necessary basis for a clear writing style. </p>
<p> </p>
<p> </p>
<p>2. It is key to back up each crucial point that you make with data. Don't just cite the study, but briefly, describe its key result(s) in a sentence or two, and explain, explicitly, why this supports your point.</p>
<p> </p>
<p> </p>
<p>Any statements of nonobvious fact (e.g. "monkeys can follow gaze", or "dopamine is necessary for motor function") should be followed by a reference (even if only to a textbook).</p>
<p> </p>
<p> </p>
<p>3. Proof: Note that the logic of scientific discovery is that of generating a list of possibilities (postulating hypotheses) and then doing experiments to test them. We proceed by rejecting false hypotheses, rather than proving true ones.</p>
<p> </p>
<p> </p>
<p> </p>
<p> </p>
<p> </p>
<p><strong>(What counts as a good argument, or a solid conclusion? There is room for considerable creativity here, depending on the topic. It is easier to say what does not count as a good conclusion.</strong></p>
<p> </p>
<p> </p>
<p><strong>For example, you should never just review a study or studies, and conclude that "more work is necessary".</strong></p>
<p> </p>
<p> </p>
<p><strong>More work is always necessary, and YOUR work in this essay is to reach a more substantive conclusion than that.</strong></p>
<p> </p>
<p> </p>
<p><strong>A recapitulation of some experiments with no substantive conclusions does not constitute a good essay, however accurate.)</strong></p>
<p> </p>
<p> </p>
