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2017.06.02 YS

1,913 bytes added, 16:56, 6 June 2017
Created page with "<ul> <li>Marker</li> <li>SNP(Single Nucleotide Polymorphism)</li> </ul> <p style="margin-left: 40px;">⇒ is a variation in a single <a href="https://en.wikipedia.org/..."
<ul>
<li>Marker</li>
<li>SNP(Single Nucleotide Polymorphism)</li>
</ul>

<p style="margin-left: 40px;">&rArr; is a variation in a single&nbsp;<a href="https://en.wikipedia.org/wiki/Nucleotide" title="Nucleotide">nucleotide</a>&nbsp;that occurs at a specific position in the&nbsp;<a href="https://en.wikipedia.org/wiki/Genome" title="Genome">genome</a>, where each variation is present to some appreciable degree within a population.[1]</p>

<p style="margin-left: 40px;">&rArr; 한개의 염기서열이 바뀐 부분을 말한다</p>

<ul>
<li>Functional genomics</li>
<li>Transcription / Translation</li>
</ul>

<p style="margin-left: 40px;">&rArr; Transcription : reflection (mirror) / DNA &rarr; RNA</p>

<p style="margin-left: 40px;">&rArr; Translation : make different / 3 base pair(codon)&nbsp;&rarr; 1 Amino acid</p>

<ul>
<li>DNA / RNA</li>
</ul>

<p style="margin-left: 40px;">&rArr; 가장 큰 차이점은 oxygen</p>

<p style="margin-left: 40px;">&rArr; DNA는 oxygen이 없기때문에 stable / RNA 는 oxygen이 존재함</p>

<ul>
<li>Which protein make more in cell?</li>
</ul>

<p style="margin-left: 40px;">protein A :&nbsp;stable mRNA, transcribe 5</p>

<p style="margin-left: 40px;">protein B : unstable mRNA, transcribe 100</p>

<p style="margin-left: 40px;">&rArr; answer is A</p>

<p style="margin-left: 40px;">&nbsp; &nbsp;stable 한 mRNA가 cell 내에 더 오래 머물기 때문에 더 많은 protein을 만든다.&nbsp;</p>

<p style="margin-left: 40px;"><img alt="" src="/ckfinder/userfiles/images/%EA%B7%B8%EB%A6%BC.png" style="height:150px; width:300px" /></p>

<p style="margin-left: 40px;">blue is A , red is B</p>

<ul>
<li>Hidden markov&nbsp;model (HMM)</li>
<li>RNA는 environment change에 따라 차이가 있으니까 연구에 활용 가능할 듯.</li>
</ul>

<p>&nbsp;</p>

<ul>
</ul>

<p>[1]&nbsp;https://en.wikipedia.org/wiki/Single-nucleotide_polymorphism</p>

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