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<p>Contents:</p> <p>1.Abstract</p> <p>2.Introduction</p> <p>3.The problem</p> <p>4.My idea</p> <p>5.The details</p> <p>6.Related works</p> <p>7.References </p>
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<p><span style="font-size:14px"><span style="font-family:arial,helvetica,sans-serif"><img src="/ckfinder/userfiles/images/vegf%20(2).png" style="float:left; height:280px; width:570px" /></span></span></p>
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<p> </p> <p><span style="font-size:14px"><span style="font-family:arial,helvetica,sans-serif"> According to outcome, 21 amino acid changes in VEGF co regulated chemokine 1 were observed, among them 12 amino acid had non-synonymous variation. These modifications could lead to specific features to the angiogenesis. There are also more proteins that responsible to new vessel formation in organism. So further research indeed necessary. </span></span></p>
<p><span style="font-size:14px"><span style="font-family:arial,helvetica,sans-serif"><strong>Related works:</strong></span></span></p>
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<p><span style="font-size:14px"><span style="font-family:arial,helvetica,sans-serif"><img src="/ckfinder/userfiles/images/angiogenesis.jpg" style="float:left; height:279px; width:528px" /></span></span></p>
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<p><span style="font-size:11px"><span style="font-family:arial,helvetica,sans-serif"><strong>References: </strong></span></span></p>
<p><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[1] <cite>Rugh, David J.; Shelden, Kim E. W. (2008). "Bowhead Whale". In Perrin, William F.;</cite> <cite><a href="https://en.wikipedia.org/wiki/Bernd_W%C3%BCrsig" title="Bernd Würsig">Würsig, Bernd</a></cite><cite>; Thewissen, J. G. M.</cite> <cite>Encyclopedia of Marine Mammals</cite> <cite>(Second ed.). </cite><cite>Academic Press. p. 131.</cite> <cite><a href="https://en.wikipedia.org/wiki/International_Standard_Book_Number" title="International Standard Book Number">ISBN</a> <a href="https://en.wikipedia.org/wiki/Special:BookSources/978-0-12-373553-9" title="Special:BookSources/978-0-12-373553-9">978-0-12-373553-9</a>.</cite></span></span></p>
<p><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[2] Michael Keane, Jeremy Semeiks “Insights into the Evolution of Longevity from the Bowhead Whale Genome” Published: December 24, 2014 in Cell reports</span></span></p>
<p><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif"><a href="http://www.cell.com/cell-reports/abstract/S2211-1247(14)01019-5">http://www.cell.com/cell-reports/abstract/S2211-1247(14)01019-5</a></span></span></p>
<p><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[3] Gatesy, J., Geisler, J.H., Chang, J., Buell, C., Berta, A., Meredith, R.W., Springer, M.S., and McGowen, M.R. (2013). A phylogenetic blueprint for a modern whale. Mol. Phylogenet. Evol. 66, 479–506.</span></span></p>
<p><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[4] Tacutu, R., Craig, T., Budovsky, A., Wuttke, D., Lehmann, G., Taranukha, D., Costa, J., Fraifeld, V.E., and de Magalha˜ es, J.P. (2013). Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing. Nucleic Acids Res. 41, D1027–D1033.</span></span></p>
<p><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[5] Gilkes, Daniele M., Gregg L. Semenza, and Denis Wirtz. "Hypoxia and the extracellular matrix: drivers of tumour metastasis." Nature Reviews Cancer 14.6 (2014): 430-439.</span></span></p>
<p><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[6] Daniel Weber “Cell hypoxia: The Prime cause of Cancer on Cell level” posted to complementary oncology website in November 2, 2011.</span></span></p>
<p><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif"><a href="http://complementaryoncology.com/reports/others/cell-hypoxia-the-prime-cause-of-cancer-on-cell-level/">http://complementaryoncology.com/reports/others/cell-hypoxia-the-prime-cause-of-cancer-on-cell-level/</a></span></span></p>
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<h2><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[7] <a href="http://www.jle.com/fr/recherche/recherche.phtml?dans=auteur&texte=Christiane+Brahimi-Horn">Christiane Brahimi-Horn</a>, <a href="http://www.jle.com/fr/recherche/recherche.phtml?dans=auteur&texte=Jacques+Pouyss%C3%A9gur+">Jacques Pouysségur</a> “The role of the hypoxia-inducible factor in tumor metabolism growth and invasion”. Published in 2006 on <a href="https://www.google.co.kr/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwiy1Ljl4dTQAhVLTbwKHXasC0oQjhwIBQ&url=http%3A%2F%2Fwww.jle.com%2Ffr%2Frevues%2Fbdc%2Fe-docs%2Fthe_role_of_the_hypoxia_inducible_factor_in_tumor_metabolism_growth_and_invasion_269705%2Farticle.phtml%3Ftab%3Dimages&bvm=bv.139782543,d.dGc&psig=AFQjCNHOAtqOfUdlhbjU4ER9GFPRkQmsag&ust=1480742493553300" target="_blank">John Libbey Eurotext</a> websit <a href="http://www.jle.com/fr/revues/bdc/e-docs/the_role_of_the_hypoxia_inducible_factor_in_tumor_metabolism_growth_and_invasion_269705/article.phtml">http://www.jle.com/fr/revues/bdc/e-docs/the_role_of_the_hypoxia_inducible_factor_in_tumor_metabolism_growth_and_invasion_269705/article.phtml</a></span></span></h2>
<h2><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[8] Harris AL, “Hypoxia: a key regulatory factor in tumor growth”, National Review in Cancer 2002 January; 2(1): p. 38-47.</span></span></h2>
<h2><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[9] Sequence details CXCL17 bmy_22314 (Coding sequence)</span></span></h2>
<h2><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif"><a href="http://www.bowhead-whale.org/annotations/details/bmy_22314/">http://www.bowhead-whale.org/annotations/details/bmy_22314/</a></span></span></h2>
<h2><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">VEGF co-regulated chemokine 1 precursor (Human) <a href="https://www.ncbi.nlm.nih.gov/protein/NP_940879">https://www.ncbi.nlm.nih.gov/protein/NP_940879</a></span></span></h2>
<h2><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">Homo sapiens C-X-C motif chemokine ligand 17 (CXCL17) <a href="https://www.ncbi.nlm.nih.gov/nuccore/NM_198477">https://www.ncbi.nlm.nih.gov/nuccore/NM_198477</a></span></span></h2>
<h2><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[10] Blast results: <a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi">https://blast.ncbi.nlm.nih.gov/Blast.cgi</a></span></span></h2>
<h2><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[11] Shih T, Lindley C. Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies. Clinical Therapeutics 2006; 28(11):1779–1802. </span></span></h2>
<h2><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[12] Gotink KJ, Verheul HM. Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action? Angiogenesis 2010</span></span></h2>
<h2><span style="font-size:11px10px"><span style="font-family:arial,helvetica,sans-serif">[13] By Melissa Hogenboom “The animal that does not get cancer” on BBC website, posted 31 October 2015 <a href="http://www.bbc.com/earth/story/20151031-the-animal-that-doesnt-get-cancer">http://www.bbc.com/earth/story/20151031-the-animal-that-doesnt-get-cancer</a></span></span></h2>
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