How many 'novel snp's are in Human? Homework

2016 Genomics

Homework

How many 'novel snp's are in Human?

20141497

Chaeeun Lee

Abstract

Firstly, SNP means single-nucleotide polymorphism variation. It occurs at a specific position, and the single nucleotide become different in that location. Also, novel SNP means it is SNP but had not been known. It is important because it can be used as markers for sequencing to find ethnic groups or genetic diseases.

Introduction

In case of novel SNP, it had been already not known, so we don’t know how many novel SNPs are in our body.

However, as considering each person, we can estimate the number of novel SNPs in one person which can be different from others.

To begin with, we have our genetic information from our ancestor. So it can be diverse according to their ancestor. Also, during DNA replication, mutation occurs. Consequently, the number of point mutation in one person means how many different sequences are in the person which is different from others.

Result

Let’s assume that 30 generations are different between Min-Ji and Chaeeun. Also, Chaeeun and Minji are both 21 years old.

-The mutation rate of human is estimated to be ~2.5×10^(−8) per base per generation

-Human mutation rate is approximately 0.5×10^(−9) per base pair per year.

So, the difference occured by generations is

(~2.5×10^(−8)per base pair per generation) * 30generations * 6469.66Mb base pairs =4852.2

In case of the mutation in each year which occur after Chaeeun is born ,

0.5×10^(−9) per base pair per year * 21 years * 6469.66Mb base pairs =67.93143

So there are about 4920 Novel SNP in Chaeeun comparing with Minji.

Reference

https://en.wikipedia.org/wiki/Single-nucleotide_polymorphism

http://genome.sph.umich.edu/wiki/SNP_Call_Set_Properties