Chapter !3 - Mapping, Sequencing, Annotation and databases Code : KSI0012

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<Index of Chapter 3>

Classical genetics as background

   -What is a gene?

Maps and tour guides 

   - Genetic maps

   - Linkage

   - Linkage disequilibrium

   - Chromosome banding pattern maps

   - High- resoultion maps, based directly on DNA sequences

   - Restriction maps 

Discovery of the structure of DNA

DNA sequencing 

   - Frederick Sanger and the development of DNA sequencing

   - The Maxam-Gilbert chemical cleavage method. 

   - Automated DNA sequencing

Organizing a large- scale sequencing project

   - Bring on the clones : hierachical - or ' BAC - to BAC' - genome sequencing 

   - Whole genome shotgun sequencing

   - High- throughput sequencing 

   - Life in the fast lanes

Databanks in molecular biology

   - Nucleic acid sequence databases

   - Protein sequence databases

   - Databases of genetic diseases -OMIM and OMIA  

   - Databases of structures

   - Classifications of protein structures

   - Specialized or 'boutique' databases

   - Databases of metabolic pathways

   - Bibiographic databases 

   - Survery of moleucular biology databases and servers 

 

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