Chapter !11 - Systems Biology Code : KSI0020

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<Index of Chapter 11>

Introduction to systems biology

-Two parallel networks : physical and logical

-Statics and dynamics of networks

Pictures of networks as graphs

-Trees

Sources of ideas for systems biology

-Complexity of sequences

-Shannon's definition of entropy

-Randomness of sequences

-Static and dynamic complexity

-Computational complexity

The metabolome

-Classification and assignment of protein function

-Metabolic networks 

-Databases of metabolic pathways

-Methionine synthesis in Escherichia coli

-The kyoto Encyclopedia of genes and genomes (KEGG)

-Evolution and phylogeny of metabolic pathways

-Carbohydrate metabolism in archaea

-Reconstruction of metabolic networks

Regulatory networks

-Signal transduction and transcriptional control

-Structures of regulatory networks

Dynamics , stability , and robustness

-Robustness through redundancy

-Dynamic modelling

Protein interaction networks

-Structural biology of regulatory networks

Protein-DNA interactions

-Structural themes in protein-DNA binding and sequence recognition

-An album of transcription regulators

Gene regulation 

-The transcriptional regulatory network of Escherichia coli

-Regulation of the lactose operon in E.Coli.

The genetic regulatory network od Saccharomyces cerevisiae

-Adaprability of the yeast regulatory network.

 

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