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Seongwan's Transcriptomics

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<h1>Relation between genomics and transcriptomicsand proteomics.</h1>

However, RNA undergoes many different procedure, it gets its own properties.

<h1p> mRNA include genetic information, codon. By the sequenced codon, ribosomes translate the mRNA into protein.</~~h1>~~ ~~<h1> </h1~~p>

<h1p> During the transcription and the translation, many regulation mechanism is existed to control the amount of expression of genome.</h1p>

<h1>~~classification of RNA molecule~~What are mRNAs?</h1>

<h2h3>Messenger RNA (mRNA) </h2h3>

<p~~>Messenger RNA</strong~~>~~ (mRNA)~~ is a large family of <a href="http://en.wikipedia.org/wiki/RNA" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="RNA">RNA</a> molecules that convey <a class="mw-redirect" href="http://en.wikipedia.org/wiki/Genetic_information" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Genetic information">genetic information</a> from <a href="http://en.wikipedia.org/wiki/DNA" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="DNA">DNA</a> to the <a href="http://en.wikipedia.org/wiki/Ribosome" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Ribosome">ribosome</a>, where they specify the <a href="http://en.wikipedia.org/wiki/Amino_acid" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Amino acid">amino acid</a>sequence of the <a href="http://en.wikipedia.org/wiki/Protein" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Protein">protein</a> products of <a href="http://en.wikipedia.org/wiki/Gene_expression" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Gene expression">gene expression</a>. Following <a href="http://en.wikipedia.org/wiki/Transcription_(genetics)" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Transcription (genetics)">transcription</a> of <a href="http://en.wikipedia.org/wiki/Primary_transcript" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Primary transcript">primary transcript</a> mRNA (known as <a href="http://en.wikipedia.org/wiki/Precursor_mRNA" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Precursor mRNA">pre-mRNA</a>) by <a href="http://en.wikipedia.org/wiki/RNA_polymerase" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="RNA polymerase">RNA polymerase</a>, processed, mature mRNA is <a class="mw-redirect" href="http://en.wikipedia.org/wiki/Translation_(genetics)" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Translation (genetics)">translated</a> into a polymer of amino acids.

In <a href="http://en.wikipedia.org/wiki/Molecular_genetics" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Molecular genetics">molecular genetics</a>, an untranslated region (or UTR) refers to either of two sections, one on each side of a <a class="mw-redirect" href="http://en.wikipedia.org/wiki/Coding_sequence" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Coding sequence">coding sequence</a> on a strand of <a class="mw-redirect" href="http://en.wikipedia.org/wiki/MRNA" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="MRNA">mRNA</a>. If it is found on the 5' side, it is called the <a href="http://en.wikipedia.org/wiki/Five_prime_untranslated_region" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Five prime untranslated region">5' UTR</a> (or leader sequence), or if it is found on the 3' side, it is called the <a href="http://en.wikipedia.org/wiki/Three_prime_untranslated_region" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Three prime untranslated region">3' UTR</a> (or trailer sequence).

Polyadenylation is the addition of a poly(A) tail to a <a class="mw-disambig" href="http://en.wikipedia.org/wiki/Messenger" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Messenger">messenger</a> <a href="http://en.wikipedia.org/wiki/RNA" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="RNA">RNA</a>. The poly(A) tail is important for the nuclear export, translation, and stability of mRNA. The tail is shortened over time, and, when it is short enough, the mRNA is enzymatically degraded.

<h2h3>ncRNA</h2h3>

A non-coding RNA (ncRNA) is a functional <a href="http://en.wikipedia.org/wiki/RNA" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="RNA">RNA</a> molecule that is not <a class="mw-redirect" href="http://en.wikipedia.org/wiki/Translation_(genetics)" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Translation (genetics)">translated</a> into a <a href="http://en.wikipedia.org/wiki/Protein" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Protein">protein</a>. Non-coding RNA genes include highly abundant and functionally important RNAs such as <a href="http://en.wikipedia.org/wiki/Transfer_RNA" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Transfer RNA">transfer RNAs</a> (tRNAs) and <a href="http://en.wikipedia.org/wiki/Ribosomal_RNA" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="Ribosomal RNA">ribosomal RNAs</a>(rRNAs), as well as RNAs such as <a href="http://en.wikipedia.org/wiki/MicroRNA" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="MicroRNA">microRNAs</a>, <a class="mw-redirect" href="http://en.wikipedia.org/wiki/SiRNA" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="SiRNA">siRNAs</a>, and <a class="mw-redirect" href="http://en.wikipedia.org/wiki/SnRNA" style="font-size: 14px; text-decoration: none; font-family: sans-serif; background-image: none; color: rgb(11,0,128); line-height: 22px" title="SnRNA">snRNAs</a>.

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