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<p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt; text-indent: -18pt; mso-list: l0 level1 lfo1"h1><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black; mso-fareast-font-family: Arial"><span style="mso-list: Ignore12px">1.<span style="font: 7pt "Times New Roman"">ATAD5 </span></span></span><span lang="EN-US" style="font-size: 13.5pt; font-ATPase family: "Arial",sans-serif; color: black">What is transcriptomics?<o:p></o:p></span></p><p style="background: white; margin: 4.8pt 0cm 6pt 20pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 13.5pt; font-family: AAA domain containing 5 ["Arial",sans-serifnbsp; color: black">Thranscriptomics is discipline of biology that study about the set of all RNA moleculs, including mRNA, rRNA, tRNA and non-coding RNA transcribed in one cell or a population of cells<o:pem>Homo sapiens</o:p></span></p><p style="background: white; margin: 4.8pt 0cm 6pt 20pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black"><o:pem> </o:p>(human) ]</span></ph1> <p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt; text-indent: -18pt; mso-list: l0 level1 lfo1"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black; mso-fareast-font-family: Arial"><span style=12px"mso-list: Ignore">2.<span style="font: 7pt "Times New Roman""> </span></span></span><span lang="EN-US" style="font-size: 13.5pt; font-familyGene ID: "Arial"79915,sans-serif; color: black">Relationship between genomics and transcriptomics<o:p></o:p></span></p><p style="background: white; margin: 4.8pt 0cm 6pt 20pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 13.5pt; fontupdated on 26-family: "Arial",sansMay-serif; color: black">Transcriptomics is expressional genomics. <o:p></o:p>2016</span></p><p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 9.5pt; font-family: "Arial",sans-serif; color: black"><o:p> </o:p></span></p><p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt; text-indent: -18pt; mso-list: l0 level1 lfo1"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black; mso-fareast-font-family: Arial"><span style="mso-list: Ignore">3.<span style="font: 7pt "Times New Roman"12px"> lt; </span></span></span><span lang="EN-US" style="font-size: 13i want to understand about PCNA and ATAD5 role.5pt; font-family: "Arialso pick that",sans-serifgt; color: black">What are mRNAs?<o:p></o:p></span></p> <p style="background: white; margin: 4.8pt 0cm 6pt 20pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black12px">mRNA is large family of RNA molecules that convey genetic information source comes from DNA to the ribosome, where they specify the amino acid sequence if the protein products of gene expressing<o:p></o:p></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 40pt"><span lang="EN-US" style="font-size: 9.5pt; font-family: "Arial",sans-serif; color: black; line-height: 107%"><o:p> </o:p></span></p><p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 9.5pt; font-family: "Arial",sans-serif; color: black"><o:p> </ohttp:p></span></p><p style="background: white; margin: 4www.8pt 0cm 6pt 38pt; line-height: 14ncbi.3pt; text-indent: -18pt; mso-list: l0 level1 lfo1"><span lang="EN-US" style="font-size: 13nlm.5pt; font-family: "Arial",sans-serif; color: black; mso-fareast-font-family: Arial"><span style="mso-list: Ignore">4nih.<span style="font: 7pt "Times New Roman""> <gov/span><protein/span></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black">How to measure RNA expression26080431?<o:p></o:p></span></p><p stylereport="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif">RNA-seq method is frequently used for measuring RNA expression.<o:p></o:p>fasta</span></p><p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 9.5pt; font-family: "Arial",sans-serif; color: black"><o:p> </o:p></span></p><p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt"h1><span lang="EN-US" style="font-size: 9.5pt; font-ATPase family: "Arial",sansAAA domain-serif; color: black"><o:p> </o:p></span></p><p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt; text-indent: -18pt; mso-list: l0 level1 lfo1"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black; mso-fareast-font-family: Arial"><span style="mso-list: Ignore">containing protein 5.<span style="font: 7pt "Times New Roman""> </span></span></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black">Relationship between Transcriptome and Proteome.<o:p>[Homo sapiens]</o:p></span></ph1><p style="background: white; margin: 4.8pt 0cm 6pt; line-height: 14.3pt; text-indent: 20.25pt; mso-char-indent-count: 1.5"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black">Proteome is expressional Transcriptome. <o:p></o:p></span></p><p class="MsoListParagraph" style="margin: 0cm 0cm 8pt 40pt"><span lang="EN-US" style="font-sizeNCBI Reference Sequence: 9NP_079133.5pt; font-family: "Arial",sans-serif; color: black; line-height: 107%"><o:p> </o:p></span>3</p><p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 9.5pt; font-family: "Arial",sans-serif; color: black"><o:p> </o:p></span></p><p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt; text-indent: -18pt; mso-list: l0 level1 lfo1"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black; mso-fareast-font-family: Arial"><span style="mso-list: Ignore">6.<span style="font: 7pt "Times New Roman""> </span></span></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black">What is a UTR?<o:p></o:p></span></ppre><p style="background: white; margin: 4.8pt 0cm 6pt 20pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial"gt;,sans-serif; background: white; mso-bidi-font-weight: bold">Untranslated region </span><span lang="EN-US" style="font-size: 13gi|26080431|ref|NP_079133.5pt; font-3| ATPase family: "Arial",sansAAA domain-serif; background: white">(or<span class="apple-converted-space"> </span><span style="mso-bidi-font-weight: bold">UTR</span>) refers to either of two sections, one on each side of a<span class="apple-converted-space"> </span></span><span lang="EN-US"><a title="Coding sequence" href="http://en.wikipedia.org/wiki/Coding_sequence"><span style="font-size: 13.5pt; text-decoration: none; font-family: "Arial",sans-serif; background: white; color: windowtext; text-underline: none">coding sequence</span></a></span><span class="apple-converted-space"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; background: white"> </span></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; background: white">on a strand of<span class="apple-converted-space"> </span></span><span lang="EN-US"><a title="MRNA" href="http://en.wikipedia.org/wiki/MRNA"><span style="font-size: 13.5pt; text-decoration: none; font-family: "Arial",sans-serif; background: white; color: windowtext; text-underline: none">mRNA</span></a></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; background: white">. If it is found on the containing protein 5' side, it is called the<span class="apple-converted-space"> </span></span><span lang="EN-US"><a title="Five prime untranslated region" href="http://en.wikipedia.org/wiki/Five_prime_untranslated_region"><span style="font-size: 13.5pt; text-decoration: none; font-family: "Arial",sans-serif; background: white; color: windowtext; text-underline: none">5' UTR</span></a></span><span class="apple-converted-space"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; background: white"> </span></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; background: white">(or<span class="apple-converted-space"> </span><span style="mso-bidi-font-weight: bold">leader sequence</span>), or if it is found on the 3' side, it is called the<span class="apple-converted-space"> </span></span><span lang="EN-US"><a title="Three prime untranslated region" href="http://en.wikipedia.org/wiki/Three_prime_untranslated_region"><span style="font-size: 13.5pt; text-decoration: none; font-family: "Arial",sans-serif; background: white; color: windowtext; text-underline: none">3' UTR</span></a></span><span class="apple-converted-space"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; background: white"> </span></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; background: white">(or<span class="apple-converted-space"> </span><span style="mso-bidi-font-weight: bold">trailer sequence</span>).<o:p></o:p></span></p>[Homo sapiens]MVGVLAMAAAAAPPPVKDCEIEPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFAPPKPSNILDYFRKTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENNKGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLNAIKTFMATTKR<p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif"><o:p> </o:p></span></p>PVILTTSDPTFSLMFDGCFEEIKFSTPSLLNVASYLQMICLTENFRTDVKDFVTLLTANTCDIRKSILYL<p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt; text-indent: -18pt; mso-list: l0 level1 lfo1"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black; mso-fareast-font-family: Arial"><span style="mso-list: Ignore">7.<span style="font: 7pt "Times New Roman""> </span></span></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black">What is ncRNA ?<o:p></o:p></span></p>QFWIRSGGGVLEERPLTLYRGNSRNVQLVCSEHGLDNKIYPKNTKKKRVDLPKCDSGCAETLFGLKNIFS<p class="MsoNormal" style="margin: 0cm 0cm 8pt 15pt; mso-para-margin-left: 1.5gd"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; background: white; line-height: 107%">A<span class="apple-converted-space"> </span><span style="mso-bidi-font-weight: bold">non-coding RNA</span><span class="apple-converted-space"> </span>(<span style="mso-bidi-font-weight: bold">ncRNA</span>) is a functional<span class="apple-converted-space"> </span></span><span lang="EN-US"><a title="RNA" href="http://en.wikipedia.org/wiki/RNA"><span style="font-size: 13.5pt; text-decoration: none; font-family: "Arial",sans-serif; background: white; color: windowtext; line-height: 107%; text-underline: none">RNA</span></a></span><span class="apple-converted-space"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; background: white; line-height: 107%"> </span></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; background: white; line-height: 107%">molecule that is not<span class="apple-converted-space"> </span></span><span lang="EN-US"><a title="Translation (genetics)" href="http://en.wikipedia.org/wiki/Translation_(genetics)"><span style="font-size: 13.5pt; text-decoration: none; font-family: "Arial",sans-serif; background: white; color: windowtext; line-height: 107%; text-underline: none">translated</span></a></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; background: white; line-height: 107%"> into a<span class="apple-converted-space"> </span></span><span lang="EN-US"><a title="Protein" href="http://en.wikipedia.org/wiki/Protein"><span style="font-size: 13.5pt; text-decoration: none; font-family: "Arial",sans-serif; background: white; color: windowtext; line-height: 107%; text-underline: none">protein</span></a></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; line-height: 107%"><o:p></o:p></span></p>PSEDLFSFLKHKITMKEEWHKFIQLLTEFQMRNVDFLYSNLEFILPLPVDTIPETKNFCGPSVTVDASAA<p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 9.5pt; font-family: "Arial",sans-serif; color: black"><o:p> </o:p></span></p>TKSMNCLARKHSEREQPLKKSQKKKQKKTLVILDDSDLFDTDLDFPDQSISLSSVSSSSNAEESKTGDEE<p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 9.5pt; font-family: "Arial",sans-serif; color: black"><o:p> </o:p></span></p>SKARDKGNNPETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRNDFSWT<p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 9.5pt; font-family: "Arial",sans-serif; color: black"><o:p> </o:p></span></p>NGKVTSGLCDEFSLESNDGWTSQSSGELKAAAEALSFTKCSSAISKALETLNSCKKLGRDPTNDLTFYVS<p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 9.5pt; font-family: "Arial",sans-serif; color: black"><o:p> </o:p></span></p>QKRNNVYFSQSAANLDNAWKRISVIKSVFSSRSLLYVGNRQASIIEYLPTLRNICKTEKLKEQGKSKRRF<p style="background: white; margin: 4.8pt 0cm 6pt 38pt; line-height: 14.3pt; text-indent: -18pt; mso-list: l0 level1 lfo1"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black; mso-fareast-font-family: Arial"><span style="mso-list: Ignore">8.<span style="font: 7pt "Times New Roman""> </span></span></span><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black">What is poly A?<o:p>LHYFEGIHLDIPKETVNTLAADFP</o:p></span></p><p style="background: white; margin: 4.8pt 0cm 6pt 20pt; line-height: 14.3pt"><span lang="EN-US" style="font-size: 13.5pt; font-family: "Arial",sans-serif; color: black">Poly A is long tail sequence of adenine nucleotides add it the 3’end of the pre-mRNA. This promotes export from the nucleus and translation, and protects the mRNA from degradation<o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 8pt"><span lang="EN-US"><o:p><font size="2" face="맑은 고딕"> </font></o:p></span></p>
<p> </p>
<p> </p>
<p>result : http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S274747/</p>
<p> http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S274747/</p>
<p> <a href="http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S274747/S274747_results.tar.bz2">http://zhanglab.ccmb.med.umich.edu/I-TASSER/output/S274747/S274747_results.tar.bz2</a></p>
