<pdiv>&nbsp;</p><h1 class="article-heading" span style="margin: 0px 0px 20px; padding: 0px; font-size: 28.799999237060547px; fontx-weight: normallarge; color: rgb(34, 34, 34); line-height: 1.173">The tiger genome and comparative analysis with lion and snow leopard genomes</span></div><div>&nbsp; font-family: arial</div><div>Yun Sung Cho, helveticaLi Hu, 'ＭＳ Ｐゴシック'Haolong Hou, 'ＭＳ ゴシック'Hang Lee, Jiaohui Xu, Soowhan Kwon, Sukhun Oh, Hak-Min Kim, OsakaSungwoong Jho, 'MS PGothic'Sangsoo Kim, sansYoung-serif;">The tiger genome and comparative analysis with lion and snow leopard genomes</h1><ul class="authors citationAh Shin, Byung Chul Kim, Hyunmin Kim, Chang-authors" style="margin: 0px 0px 10px; padding: 0px; fontuk Kim, Shu-weight: bold; color: rgb(51Jin Luo, Warren E. Johnson, 51Klaus-Peter Koepfli, 51)Anne Schmidt-K&uuml; font-family: arialntzel, helveticaJason A. Turner, 'ＭＳ Ｐゴシック'Laurie Marker, 'ＭＳ ゴシック'Cindy Harper, OsakaSusan M. Miller, 'MS PGothic'Wilhelm Jacobs, sans-serif; font-size: 14Laura D.399999618530273px; lineBertola, Tae Hyung Kim, Sunghoon Lee, Qian Zhou, Hyun-height: 23.912500381469727px;"> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-1" class="name" style="color: rgb(92Ju Jung, Xiao Xu, Priyvrat Gadhvi, Pengwei Xu, Yingqi Xiong, Yadan Luo, Shengkai Pan, 121Caiyun Gou, 150); text-decoration: none;"><span class="fn">Yun Sung Cho</span></a><span class="comma">Xiuhui Chu, Jilin Zhang, Sanyang Liu,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-2" class="name" style="color: rgb(92Jing He, Ying Chen, Linfeng Yang, Yulan Yang, Jiaju He, Sha Liu, Junyi Wang, Chul Hong Kim, 121Hwanjong Kwak, 150); textJong-decoration: none;"><span class="fn">Li Hu</span></a><span class="comma">Soo Kim, Seungwoo Hwang, Junsu Ko,Chang-Bae Kim, Sangtae Kim, Damdin Bayarlkhagva, Woon Kee Paek, Seong-Jin Kim, Stephen J. O&rsquo;Brien, Jun Wang &amp; [[Jong Bhak]]</span></lidiv> <li class="vcard" style="margin: 0pxdiv>&nbsp; padding: 0px; list-style: none; display: inline;"</div><div>[[AffiliationsContributionsCorresponding authors]]<a href="http:/div><div>&nbsp;</www.naturediv><div>Nature Communications 4, Article number: 2433 doi:10.com1038/ncommsncomms3433</div><div>Received 02 May 2013 Accepted 13 August 2013 Published 17 September 2013</130917div><div>&nbsp;</ncomms3433div><div>&nbsp;</full/ncomms3433.html#auth-3" class="name" div><div><b><span style="color: rgb(92, 121, 150); textfont-decorationsize: nonelarge;">Abstract</span class="fn">Haolong Hou</spanb></adiv><span class="comma"div>,</span></li> <li class="vcard" style="margincolor: 0pxrgb(51, 51, 51); padding: 0px; listfont-stylefamily: none; display: inline;"><a href="httparial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; font-size://www14.nature399999618530273px; line-height: 23.com/ncomms/2013912500381469727px;">Tigers and their close relatives (</130917/ncomms3433/full/ncomms3433.html#auth-4" class="name" span><i style="color: rgb(9251, 12151, 15051); textfont-decorationfamily: none;"><span class="fnarial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">Hang Lee</span>Panthera</ai><span classstyle="comma">color: rgb(51, 51,</span></li> <li class="vcard" style="margin: 0px51); padding: 0px; listfont-stylefamily: none; display: inline;"><a href="httparial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; font-size://www14.nature399999618530273px; line-height: 23.com/ncomms912500381469727px;">) are some of the world&rsquo;s most endangered species. &nbsp;Here we report the&nbsp;</2013/130917/ncomms3433/full/ncomms3433.html#auth-5" class="name" span><i style="color: rgb(9251, 12151, 15051); textfont-decorationfamily: none;"><span class="fn">Jiaohui Xu</span></a><span class="comma">arial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック',</span></li> <li class="vcard" style="margin: 0pxOsaka, 'MS PGothic', sans-serif; paddingfont-size: 0px14.399999618530273px; listline-styleheight: none; display: inline23.912500381469727px;">de novo<a href/i><span style="httpcolor://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-6" class="name" style="color: rgb(92rgb(51, 12151, 15051); textfont-decorationfamily: none;"><span class="fnarial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">Soowhan Kwon&nbsp;assembly of an Amur tiger whole-genome sequence as well as the genomic sequences of a white Bengal tiger, African lion, white African lion and snow leopard. &nbsp;Through comparative genetic analyses of these genomes, we find genetic signatures that may reflect molecular adaptations consistent with the big cats&rsquo; hypercarnivorous diet and muscle strength. &nbsp;We report a snow leopard-specific genetic determinant in&nbsp;</span></a><span class="comma">i style="color: rgb(51, 51,</span></li> <li class="vcard" style="margin: 0px51); padding: 0px; listfont-stylefamily: none; display: inlinearial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">EGLN1<a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-7" class="name" /i><span style="color: rgb(9251, 12151, 15051); textfont-decorationfamily: none;"><span class="fnarial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;">Sukhun Oh</span></&nbsp;(Met39&gt;Lys39), which is likely to be associated with adaptation to high altitude. &nbsp;We also detect a><span class="comma">,&nbsp;</span></li> <li class="vcard" i style="margincolor: 0px; padding: 0px; listrgb(51, 51, 51); font-stylefamily: nonearial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; displayfont-size: inline14.399999618530273px;"line-height: 23.912500381469727px;">TYR<a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-8" class="name" i><span style="color: rgb(9251, 12151, 15051); textfont-decorationfamily: none;arial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;"><span class="fn">Hak-Min Kim260G&gt;A mutation likely responsible for the white lion coat colour. &nbsp;Tiger and cat genomes show similar repeat composition and an appreciably conserved synteny. &nbsp;Genomic data from the five big cats provide an invaluable resource for resolving easily identifiable phenotypes evident in very close, but distinct, species.</span></adiv><span class="comma"div>,&nbsp;</spandiv></lidiv> <li class="vcard" style="margin: 0px&nbsp; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-9" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Sungwoong Jho</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-10" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Sangsoo Kim</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-11" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Young-Ah Shin</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-12" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Byung Chul Kim</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-13" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Hyunmin Kim</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-14" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Chang-uk Kim</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-15" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Shu-Jin Luo</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-16" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Warren E. Johnson</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-17" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Klaus-Peter Koepfli</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-18" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Anne Schmidt-K&uuml;ntzel</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-19" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Jason A. Turner</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-20" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Laurie Marker</span></a><span class="comma" style="display: inline;">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-21" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Cindy Harper</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-22" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Susan M. Miller</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-23" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Wilhelm Jacobs</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-24" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Laura D. Bertola</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-25" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Tae Hyung Kim</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-26" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Sunghoon Lee</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-27" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Qian Zhou</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-28" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Hyun-Ju Jung</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-29" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Xiao Xu</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-30" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Priyvrat Gadhvi</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-31" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Pengwei Xu</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-32" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Yingqi Xiong</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-33" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Yadan Luo</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-34" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Shengkai Pan</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-35" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Caiyun Gou</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-36" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Xiuhui Chu</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-37" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Jilin Zhang</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-38" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Sanyang Liu</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-39" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Jing He</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-40" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Ying Chen</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-41" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Linfeng Yang</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-42" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Yulan Yang</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-43" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Jiaju He</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-44" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Sha Liu</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-45" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Junyi Wang</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-46" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Chul Hong Kim</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-47" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Hwanjong Kwak</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-48" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Jong-Soo Kim</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-49" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Seungwoo Hwang</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-50" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Junsu Ko</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-51" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Chang-Bae Kim</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-52" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Sangtae Kim</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-53" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Damdin Bayarlkhagva</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-54" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Woon Kee Paek</span></a><span class="comma">,</span></li> <li class="vcard" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-55" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Seong-Jin Kim</span></a><span class="comma">,</span></li> <li class="vcard c1" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-56" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Stephen J. O&rsquo;Brien</span></a><span class="comma">,</span></li> <li class="vcard c1 no-comma" style="margin: 0px; padding: 0px; list-style: none; display: inline;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-57" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span class="fn">Jun Wang</span></a></li> <li class="vcard last-author c1 no-comma" style="margin: 0px; padding: 0px; list-style: none; display: inline;">&amp;&nbsp;<span style="color: rgb(0, 0, 0);">[[</span><span class="fn" style="color: rgb(92, 121, 150); text-decoration: none;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#auth-58" class="name" style="color: rgb(92, 121, 150); text-decoration: none;"><span style="color: rgb(0, 0, 0);">Jong Bha</span></a></span><span style="color: rgb(0, 0, 0);"><span class="fn" style="text-decoration: none;">k]]</span></span></li></ul><ul id="author-links" class="cleared" style="margin: 0px 0px 20px; padding: 0px; color: rgb(51, 51, 51); font-family: arial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;"> <li class="first" style="margin: 0px; padding: 0px 0.5em 0px 0px; list-style: none; float: left; background-image: none; background-attachment: scroll; background-position: 0px 0.6ex; background-repeat: no-repeat no-repeat;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#affil-auth" style="color: rgb(92, 121, 150); text-decoration: none; font-weight: bold;">Affiliations</a></li> <li style="margin: 0px; padding: 0px 0.5em; list-style: none; float: left; background-image: url(http://www.nature.com/view/images/bg_pipe.gif); background-attachment: scroll; background-position: 0px 0.6ex; background-repeat: no-repeat no-repeat;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#contrib-auth" style="color: rgb(92, 121, 150); text-decoration: none; font-weight: bold;">Contributions</a></li> <li style="margin: 0px; padding: 0px 0.5em; list-style: none; float: left; background-image: url(http://www.nature.com/view/images/bg_pipe.gif); background-attachment: scroll; background-position: 0px 0.6ex; background-repeat: no-repeat no-repeat;"><a href="http://www.nature.com/ncomms/2013/130917/ncomms3433/full/ncomms3433.html#corres-auth" style="color: rgb(92, 121, 150); text-decoration: none; font-weight: bold;">Corresponding authors</a></li></ul><dl class="citation" style="margin: 0px; padding: 0px; color: rgb(51, 51, 51); font-family: arial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;"><dd class="journal-title" style="margin: 0px; padding: 0px 3px 0px 0px; font-style: italic; text-transform: capitalize; display: inline;">Nature Communications</dd>&nbsp;<dd class="volume" style="margin: 0px; padding: 0px 3px 0px 0px; font-weight: bold; display: inline;">4<span style="font-weight: normal;">,</span></dd>&nbsp;<dt class="seq" style="margin: 0px; padding: 0px; display: inline;">Article number:</dt>&nbsp;<dd class="page" style="margin: 0px; padding: 0px 3px 0px 0px; display: inline;">2433</dd>&nbsp;<dd class="doi" style="margin: 0px 0px 0px 4px; padding: 0px 3px 0px 10px; display: inline; background-image: url(http://www.nature.com/view/images/bg_pipe.gif); background-position: 0px 0.4ex; background-repeat: no-repeat no-repeat;">doi:10.1038/ncomms3433</dd></dl><dl class="citation dates" style="margin: 0px; padding: 0px; color: rgb(51, 51, 51); font-family: arial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;"><dt class="received first" style="margin: 0px; padding: 0px 3px 0px 0px; display: inline; background-image: none !important;">Received</dt>&nbsp;<dd style="margin: 0px; padding: 0px 3px 0px 0px; display: inline;"><time datetime="2013-05-02">02 May 2013&nbsp;</time></dd><dt class="accepted" style="margin: 0px; padding: 0px 3px 0px 8px; display: inline; background-image: url(http://www.nature.com/view/images/bg_pipe.gif); background-position: 0px 0.4ex; background-repeat: no-repeat no-repeat;">Accepted</dt>&nbsp;<dd style="margin: 0px; padding: 0px 3px 0px 0px; display: inline;"><time datetime="2013-08-13">13 August 2013&nbsp;</time></dd><dt class="published-online" style="margin: 0px; padding: 0px 3px 0px 8px; display: inline; background-image: url(http://www.nature.com/view/images/bg_pipe.gif); background-position: 0px 0.4ex; background-repeat: no-repeat no-repeat;">Published</dt>&nbsp;<dd style="margin: 0px; padding: 0px 3px 0px 0px; display: inline;"><time datetime="2013-09-17">17 September 2013</time></dd></dl><dl class="citation dates" style="margin: 0px; padding: 0px; color: rgb(51, 51, 51); font-family: arial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif; font-size: 14.399999618530273px; line-height: 23.912500381469727px;"><br type="_moz" /div></dldiv><dl class="citation dates" style="margin: 0px; padding: 0px; color: rgb(51, 51, 51); font-family: arial, helvetica, 'ＭＳ Ｐゴシック', 'ＭＳ ゴシック', Osaka, 'MS PGothic', sans-serif&nbsp; font-size: 14.399999618530273px; line-height: 23.912500381469727px;"><br type="_moz" /></dldiv>