Changes

The first Korean <font size="4">Single-molecule sequencing of an individual human genome sequence publicized (data) and published (research article) is from Gacheon Medical School and KRIBB (KOBIC) of Korea.</font><br />

[[The first Korean <font color="#0066cc">SRA009216<br /></font><br /><p id="aug">Dmitry Pushkarev^{<a title="affiliated with " href="http://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt.1561.html#a1"><font color="#0066cc">1</font></a>,}^{<a title="affiliated with " href="http://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt.1561.html#a2"><font color="#0066cc">2</font></a>}, Norma F Neff^{<a title="affiliated with " href="http://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt.1561.html#a1"><font color="#0066cc">1</font></a>,}^{<a title="affiliated with " href="http://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt.1561.html#a2"><font color="#0066cc">2</font></a>} &amp; Stephen R Quake^{<a title="affiliated with " href="http://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt.1561.html#a1"><font color="#0066cc">1</font></a>}</p><p class="caff"><font color="#0066cc"></font></p><font color="#0066cc"><hr class="separator" /></font><p class="hidden"><font size="3">Billions of 24- to 70-bp reads (32 bp average)<br /><img style="BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; BORDER-RIGHT: 0px" alt="approx" src="http://www.nature.com/__chars/math/special/sim/black/med/base/glyph.gif" />90% of the National Center for Biotechnology Information (NCBI) reference genome sequence and analysis.<br />28<img style="BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; VERTICAL-ALIGN: middle; BORDER-TOP: 0px; BORDER-RIGHT: 0px" alt="times" src="http: Full genome //www.nature.com/__chars/math/special/times/black/med/base/glyph.gif" /> average coverage<br />by&nbsp;one sequencing instrument by a single operator with four data collection runs.&nbsp;<br />Single-molecule sequencing enabled analysis of human genomic information without the need for cloning, amplification or ligation.&nbsp;<br />determined <img style="BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; BORDER-RIGHT: 0px" alt="approx" src="http://www.nature.com/__chars/math/special/sim/black/med/base/glyph.gif" />2.8 million single nucleotide polymorphisms (SNPs) with a sociofalse-ethnic group]]positive rate of less than 1% as validated by Sanger sequencing and 99.8% concordance with SNP genotyping arrays.&nbsp;<br />identified 752 regions of copy number variation by analyzing coverage depth alone and validated 27 of these using digital PCR.&nbsp;<br />

NCBI accession number: [[SRA008175]]Nature Biotechnology</font><br />

<font size="4">See also[[Helicos Biosciences]]<br /></fontp>The second Korean genome accession number:&nbsp; [[SRA008370]]