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<h3>Can miRNA be available for a therapy about an intractable disease associated with a gene?</h3>
<p>Gene is the most central element to produce proteins in the body, and everything in human </p> <h4>Abstract</h4> <p>Many disease is determined by related with genethat express the some protein. and disease like And MicroRNA(miRNA) is a cancer is associated with kind of regulatory gene. It can repress the geneexpression. Recently gene therapy is developed. If so i thought 'Can miRNA can be available for a therapy one of the treatments about an intractable disease associated with a gene?'. Because miRNA can be specified target gene and interfere the translation of proteins by ribosome.</p>
<ph4>So answer is 'YES. miRNA can be available for a therapy'. Already many scientists are studying about these problem and the relationship between cancer and miRNA has been found.Introduction</ph4>
<p>but limitation Gene is the most central element to produce proteins in the body. Gene control how cell work by making proteins that have specific functions and difficulties act as messengers for the cell. Therefore, each gene must not have some errors. This is so the protein can perform the correct function for the cell. But many disease is caused by the gene that makes the some proteins. For example, cancer begins when one or more genes in a cell are mutated, or changed. This creates an abnormal protein or no protein at all. An abnormal protein provides different information than a normal protein, which can cause cells to multiply uncontrollably and become cancerous. Thus, our bodies are determined in the expression of genes. However, there is also exista mechanism in the body that prevents the expression of the gene. MicroRNA(miRNA) is a kind of regulatory gene, that functions in RNA silencing and post-transcriptional regulation of gene expression. their characteristic structure helps identify them and predict the target genes they might regulate. If so miRNA can be one of the treatments about an intractable disease associated with a gene. Because miRNA can be specified target gene and interfere the translation of proteins by ribosome.</p>
<ph4>first, Low permeation of Actually miRNA by physical and physiological barriers of is related with the cancer tissue. Because abnormal vascular structure of tumor.</ph4>
<p>secondWhen we look at the relationship between Mirna and cancer, Unintended effects they actually have quite a lot of miRNArelationships. MiRNA are generally downregulated in cancer. Because Some people already have GENE, which causes CANCER, and many miRNAs target different pathwaysare involved and blocking its expression. This was demonstrated in a MOUSE MODEL experiment. Over the past decade, unwanted gene suppression of the degree to which miRNAs are involved in cancer-suppressing genes may occurhas really become apparent. This unintended effect may cause potential toxicity or reduce As has the effectiveness sheer diversity of mechanisms by which miRNA function is deregulated, the treatmentmajor general causes of altered miRNA expression in cancer are discussed below and summarised in Figure.</p>
<h3p>related paperIf so, can these mutated miRNAs be treated and replaced?</h3p>
<ph4>Cancer gene therapy is already underway.<a href="https://wwwh4> <p>Many researchers are studying the nature of cancer and genes, and miRNA-based therapies are under development.sciencedirectAlthough it is still a trial and error step, and there are many difficulties, it is expected that perfect miRNA TREATMENTS will be developed if precise cause of GENE and CANCER is identified.com</science/article/pii/S1574789112000981"p>MicroRNA and cancer </ah4>Conclusion<br /h4>Martin D. Jansson, Anders H. Lund*<br /p>Biotech Research and Innovation Centre and Centre for Epigenetics, University MiRNA can be one of Copenhagen, Ole Maalthe treatments aboutønbsp;es Vej 5an intractable disease like the cancer. Already many scientists study the source of cancer and miRNA. Although the gene therapy is not perfect, DK-2200 Copenhagen,<br />Denmarkit has a potential as a treatment.</p>
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<td style="width:50%">http://www.ibric.org/myboard/read.php?Board=report&id=2489</td>
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<td><a href="https://www.sciencedirect.com/science/article/pii/S1574789112000981">MicroRNA and cancer</a><br />
Martin D. Jansson, Anders H. Lund*<br />
Biotech Research and Innovation Centre and Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen,<br />
Denmark</td>
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<td>https://www.cancer.net/navigating-cancer-care/cancer-basics/genetics/genetics-cancer</td>
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<td>http://www.kosen21.org/info/kosenReport/reportView.do?articleSeq=759471</td>
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<td>https://www.nature.com/cgt/about/</td>
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