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Minsu Kim/minsu1

1,776 bytes added, 22:21, 8 December 2017
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<ul>
<li>Cleavage To trigger destruction of the mRNA strand into two pieces,</li> <li>Destabilization To interfere with translation of the mRNA through shortening of its&nbsp;poly(A) tail, and</li>
<li>Less efficient&nbsp;translation&nbsp;of the mRNA into proteins by&nbsp;ribosomes</li>
</ul>
<p>miRNAs resemble the&nbsp;small interfering RNAs (siRNAs)&nbsp;of the&nbsp;RNA interference (RNAi)&nbsp;pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of&nbsp;double-stranded RNA.&nbsp;The&nbsp;human genome&nbsp;may encode over 1000 miRNAs, which are abundant in many mammalian cell types&nbsp;and appear to target about 60% of the genes of humans and other mammals</p>
 
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<h1>Question</h1>
 
<h3>Can miRNA be&nbsp;available for a&nbsp;therapy about&nbsp;an intractable disease associated with a gene?</h3>
 
<p>Gene is the most central element to produce proteins in the body, and everything in human&nbsp;is determined by gene. and disease like a&nbsp;cancer is associated with the gene. If so i thought &#39;Can miRNA be&nbsp;available for a&nbsp;therapy about&nbsp;an intractable disease associated with a gene?&#39;. Because miRNA can be specified target gene and interfere the translation&nbsp;of proteins by ribosome.</p>
 
<p>So answer is &#39;YES. miRNA can be available for a&nbsp;therapy&#39;. Already many scientists are studying about these problem&nbsp;and the relationship between cancer and miRNA has been found.</p>
 
<p>but limitation and difficulties also exist.&nbsp;</p>
 
<p>first,&nbsp;Low permeation of miRNA by physical and physiological barriers of cancer tissue. Because abnormal vascular structure of tumor.</p>
 
<p>second,&nbsp;Unintended effects of miRNA.&nbsp;Because miRNAs target different pathways, unwanted gene suppression of cancer-suppressing genes may occur. This unintended effect may cause potential toxicity or reduce the effectiveness of the treatment.</p>
 
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<h1>Reference</h1>
 
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<p>https://en.wikipedia.org/wiki/MicroRNA#Target_prediction&nbsp;</p>
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<td style="width:50%">http://www.ibric.org/myboard/read.php?Board=report&amp;id=2489</td>
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<td>molecular biology of the gene seventh edition-pearson</td>
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<td>http://www.kosen21.org/info/kosenReport/reportView.do?articleSeq=759471</td>
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