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<p>*PGE2(Prostaglandin E2)</p>
<p>-> Activate Prostaglandin receptor -> UCP1 Expression increase ->Adipose tissue transformation increase </p>
<p>*Increased Angiogenesis</p>
<p>=> Mobility of Targeted NPs to Adipose angiogenic vessel increase(Efficiency increase)</p>
<p> </p>
<p>(<a href="http://www.nature.com/nm/journal/v22/n7/full/nm0716-694.html">http://www.nature.com/nm/journal/v22/n7/full/nm0716-694.html</a>)</p>
<p>All in one: Researchers create combination drugs for diabetes and obesity</p>
<p> </p>
<p>Novelty of the combinations</p>
<p>-> Use protein engineering and chemistry</p>
<p>-> <u>Combine </u><u>two or more agents into a single molecule</u>.</p>
<p> </p>
<p>(1) GLP-1 Glucagon dual agonist</p>
<p>-> combine GLP-1(glucagon-like peptide 1) with Glucagon</p>
<p>-> Showed a nearly 5-pound weight loss in a dozen individuals</p>
<p>-> Suppress food intake</p>
<p>* Glucagon</p>
<p>-> Releases glucose into the bloodstream (unwise choice for an antidiabetic agent.)</p>
<p>-> Buffer the side effects of GLP-1 (when given in tandem)</p>
<p>-> the combination is more effective at lowering body weight than either of its components alone.</p>
<p> </p>
<ol>
<li>Why Darwin’s evolution theory is scientifically wrong?</li>
</ol>
<ul>
<li>How can we prove that?</li>
<li>Is there any alternative to replace evolution theory?</li>
</ul>
<p><a href="http://humansarefree.com/2013/12/9-scienctific-facts-prove-theory-of.html">http://humansarefree.com/2013/12/9-scienctific-facts-prove-theory-of.html</a></p>
<p> </p>
<p>2. Obesity population is different from temperature.</p>
<ul>
<li>Why does this happen?</li>
<li>Is there any difference metabolic condition from temperature?</li>
</ul>
<p><a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141724">http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141724</a></p>
<p> </p>
<p>3. What cause wild dog and cat become domestic?</p>
<ul>
<li>Is it also can be proved using evolution theory?</li>
<li>Then why wolf and fox can’t be domesticated?</li>
</ul>
<p><a href="http://www.theatlantic.com/science/archive/2016/06/the-origin-of-dogs/484976/">http://www.theatlantic.com/science/archive/2016/06/the-origin-of-dogs/484976/</a></p>
<p> </p>
<p>4. What makes people obese?</p>
<ul>
<li>What is reason?</li>
<li>How to balance our body?</li>
</ul>
<p><a href="https://www.nhlbi.nih.gov/health/health-topics/topics/obe/causes">https://www.nhlbi.nih.gov/health/health-topics/topics/obe/causes</a></p>
<p> </p>
<p>5. Why aged people easily get obesed?</p>
<ul>
<li>Is there any difference between young people?</li>
<li>How do improve metabolic rate?</li>
</ul>
<p><a href="http://ajcn.nutrition.org/content/82/5/923.full">http://ajcn.nutrition.org/content/82/5/923.full</a></p>
<p> </p>
<p>6. What is metabolically healthy obesity?</p>
<ul>
<li>How can obese people is in fact healthy?</li>
</ul>
<p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798285/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798285/</a></p>
<p> </p>
<p>7. Can gene promote obesity?</p>
<ul>
<li>How does it can happen?</li>
<li>How can we cure it?</li>
</ul>
<p><a href="https://www.hsph.harvard.edu/obesity-prevention-source/obesity-causes/genes-and-obesity/">https://www.hsph.harvard.edu/obesity-prevention-source/obesity-causes/genes-and-obesity/</a></p>
<p> </p>
<p> </p>
